Ever since its inception, the primary aim for IVF has been to, perhaps, reduce time to pregnancy for infertile couples. As clinicians, referring doctors and infertility specialists, one expects a pregnancy to be achieved as soon as possible after starting an IVF cycle. Historically, ovarian hyper stimulation followed by transfer of multiple embryos was the first step towards achieving this goal.
Nevertheless, in the bargain, we also increased the rate of multiple pregnancies and its antecedent complications along with pregnancy losses.
This in fact lead to further delay in achieving live birth of a baby. Hence forth, scientists have been in search of a strategy which could truly reduce time to pregnancy in terms of live birth rate, without raising the complication rates.
This has now been made possible to some extent by Preimplantation genetic screening (PGS) or Preimplantation genetic testing for aneuploidy (PGT-A) of embryos generated during IVF.
PGT-A helps identify genetically normal embryos known as Euploid embryos from the abnormal ones called Aneuploid. Euploid embryos, having a higher implantation potential, thus, can reassuringly be placed back into the uterus singularly, giving the highest chance of a singleton live birth in the shortest period of time